Association between cognitive function and IL-18 levels in schizophrenia: Dependent on IL18 - 607 A/C polymorphism.

Accumulating evidence suggests that immune system dysregulation is associated with debilitating neurodevelopment in schizophrenia (SZ). Cognitive impairment is a persistent feature that occurs during the onset of SZ and persists throughout the course of the disease. Early studies have found that elevated interleukin (IL)- 18 interacts with IL18 polymorphism and is correlated with psychotic symptoms in SZ. This study aimed to investigate whether elevated IL-18 levels interacted with the -607 A/C polymorphism to determine cognitive decline in patients with chronic SZ. We recruited 693 inpatients and 422 healthy controls to measure IL-18 levels and genotype the - 607 A/C polymorphism. Further, cognitive function was measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). We found that IL-18 serum levels were higher in patients than those in healthy controls, and were not associated with IL18 - 607 A/C in combined subjects or either patients or healthy controls, respectively. Moreover, - 607 A/C was correlated with the visuospatial/constructional index only in the patients. In addition, our research found that IL-18 levels were positively correlated to immediate memory only in patients with the C/C genotype, but not in patients with C/A or A/A genotype. This study suggests that the relationship of IL-18 with cognitive function depends on the IL18 - 607 A/C polymorphism of SZ patients.

Effect of Aerobic Exercise on Mental Health in Older Adults: A Meta-Analysis of Randomized Controlled Trials.

Introduction: The recommendation of exercise programs in the senior population may benefit inactive and sedentary individuals and improve and help to treat specific health conditions. The purpose of this review is to summarize the published evidence from RCT studies of aerobic exercise interventions for mental health in older adults over the last 20 years. Methods: A literature search was conducted using electronic databases including Web of Science, PubMed/Medline, and ProQuest. Results: A total of 15 studies met the inclusion criteria. The subjects of these studies were aged 60 years or older and had various physical health statuses. In 15 studies, the mean effect size for the experimental outcome was 0.56 ± 0.39 (95%CI: 0.36-0.76). One-way ANOVA indicated no significant differences in the intervention duration [F (2,15) = 0.919, p = 0.420], subject category [F (2,15) = 0.046, p = 0.955], or measurement category [F (3,14) = 0.967, p = 0.436]. However, there were significant differences in exercise frequencies [F (2,15) = 6.03, p = 0.012]. Conclusion: The available evidence suggests that aerobic exercise is beneficial for improving the mental health of adults aged 60 years and older. The intervention effect can be achieved regardless of the type of subject and the duration of the intervention. Further, the present study indicates that low-frequency, long-term and regular aerobic exercise is more effective for older adults. Therefore, we recommend that older adults to exercise at a low frequency depending on their physical condition.

Role of perceived family support in psychological distress for pregnant women during the COVID-19 pandemic.

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has caused major public panic in China. Pregnant women may be more vulnerable to stress, which may cause them to have psychological problems. AIM: To explore the effects of perceived family support on psychological distress in pregnant women during the COVID-19 pandemic. METHODS: A total of 2232 subjects were recruited from three cities in China. Through the online surveys, information on demographic data and health status during pregnancy were collected. Insomnia severity index, generalized anxiety disorder 7-item scale, patient health questionnaire-9, somatization subscale of the symptom check list 90 scale, and posttraumatic stress disorder checklist were used to assess the psychological distress. RESULTS: A total of 1015 (45.4%) women reported having at least one psychological distress. The women who reported having inadequate family support were more likely to suffer from multiple psychological distress (≥ 2 psychological distress) than women who received adequate family support. Among the women who reported less family support, 41.8% reported depression, 31.1% reported anxiety, 8.2% reported insomnia, 13.3% reported somatization and 8.9% reported posttraumatic stress disorder (PTSD), which were significantly higher than those who received strong family support. Perceived family support level was negatively correlated with depressive symptoms (r = -0.118, P < 0.001), anxiety symptoms (r = -0.111, P < 0.001), and PTSD symptoms (r = -0.155, P < 0.001). CONCLUSION: Family support plays an important part on pregnant women's mental health during the COVID-19 pandemic. Better family support can help improve the mental health of pregnant women.

Investigating the Spatiotemporal Variability and Driving Factors of Artificial Lighting in the Beijing-Tianjin-Hebei Region Using Remote Sensing Imagery and Socioeconomic Data.

With rapid urbanization and economic development, artificial lighting at night brings convenience to human life but also causes a considerable urban environmental pollution issue. This study employed the Mann-Kendall non-parametric test, nighttime light indices, and the standard deviation method to investigate the spatio-temporal characteristics of artificial lighting in the Beijing-Tianjin-Hebei region. Moreover, nighttime light imagery from the Defense Meteorological Satellite Program Operational Linescan System, socioeconomic data, and high-resolution satellite images were combined to comprehensively explore the driving factors of urban artificial lighting change. The results showed the following: (1) Overall, there was an increasing trend in artificial lighting in the Beijing-Tianjin-Hebei region, which accounted for approximately 56.87% of the total study area. (2) The change in artificial lighting in the entire area was relatively stable. The artificial lighting in the northwest area changed faster than that in the southeast area, and the areas where artificial lighting changed the most were Beijing, Tianjin and Tangshan. (3) The fastest growth of artificial lighting was in Chengde and Zhangjiakou, where the rates of increase were 334% and 251%, respectively. The spatial heterogeneity of artificial lighting in economically developed cities was higher than that in economically underdeveloped cities such as Chengde and Zhangjiakou. (4) Multi-source data were combined to analyse the driving factors of urban artificial lighting in the entire area. The Average Population of Districts under City (R2 = 0.77) had the strongest effect on artificial lighting. Total Passenger Traffic (R2 = 0.54) had the most non-obvious effect. At different city levels, driving factors varied with differences of economy, geographical location, and the industrial structures of cities. Urban expansion, transportation hubs, and industries were the major reasons for the significant change in nighttime light. Urban artificial lighting represents a trend of overuse closely related to nighttime light pollution. This study of artificial lighting contributes to the rational planning of urban lighting systems, the prevention and control of nighttime light pollution, and the creation of liveable and ecologically green cities.

Potentiality of Using Luojia 1-01 Nighttime Light Imagery to Investigate Artificial Light Pollution.

The successful launch of Luojia 1-01 complements the existing nighttime light data with a high spatial resolution of 130 m. This paper is the first study to assess the potential of using Luojia 1-01 nighttime light imagery for investigating artificial light pollution. Eight Luojia 1-01 images were selected to conduct geometric correction. Then, the ability of Luojia 1-01 to detect artificial light pollution was assessed from three aspects, including the comparison between Luojia 1-01 and the Suomi National Polar-Orbiting Partnership Visible Infrared Imaging Radiometer Suite (NPP-VIIRS), the source of artificial light pollution and the patterns of urban light pollution. Moreover, the advantages and limitations of Luojia 1-01 were discussed. The results showed the following: (1) Luojia 1-01 can detect a higher dynamic range and capture the finer spatial details of artificial nighttime light. (2) The averages of the artificial light brightness were different between various land use types. The brightness of the artificial light pollution of airports, streets, and commercial services is high, while dark areas include farmland and rivers. (3) The light pollution patterns of four cities decreased away from the urban core and the total light pollution is highly related to the economic development. Our findings confirm that Luojia 1-01 can be effectively used to investigate artificial light pollution. Some limitations of Luojia 1-01, including its spectral range, radiometric calibration and the effects of clouds and moonlight, should be researched in future studies.